The Millers is set in Leesburg, Virginia where Nathan Miller is a local television news reporter. His sister Debbie runs a combination yoga studio/vegan restaurant with her husband Adam, with whom she has a daughter named Mikayla. Nathan does not have any children and often hangs out with Ray, his friend who also serves as a cameraman for the television station at which Nathan works. As the series begins, Nathan and Debbie's bickering parents, Tom and Carol Miller, are returning from Myrtle Beach. Nathan informs them he divorced his wife, Janice, several months ago. Tom responds by deciding to leave Carol, ending their 43-year marriage. Tom moves in with Debbie and Adam while Carol moves in with Nathan, each driving their children crazy.